Professor Jorge Ruffinelli (Uruguay), a disciple of Angel Rama at the University of Uruguay, followed him as Director of the literary section of the seminal Uruguayan weekly Marcha in 1968. In 1973 he was Adjunct Professor of the Latin American literature program (directed by Noé Jitrik) at the University of Buenos Aires. In 1974 he emigrated to México, where he was appointed Director of the Centro de Investigaciones Lingüístico-Literarias at the Universidad Veracruzana, a position he held for for twelve years. At the Universidad Veracruzana he was also Professor in the school of Letters, and collaborated in all the major cultural journals and newspapers of the Latin American continent. In 1986 he was appointed Full Professor in the Department of Spanish and Portuguese at Stanford. In Mexico he founded and directed the literary journal Texto crítico for twelve years. A member of various international editorial boards, in the United States he has directed the journal Nuevo texto crítico since 1987.
He has published twenty books of literary and cultural criticism and more than five hundred articles, critical notes and reviews in journals throughout the world. A recognized authority on Onetti, García Márquez, Juan Rulfo, and Latin American literary history, during the nineties his critical work has centered on Latin American cinema. In 1993 he filmed a documentary on Augusto Monterroso for which he interviewed major Mexican writers and critics. He is completing the first Encyclopedia of Latin American Cinema, for which he has written around two thousand articles on feature films from and about Latin America. His current work also includes a book of interpretation and survey of the most recent Spanish American prose published by writers born after 1968, a project that analyzes the work, marketing, and reception of over more than fifty authors (Ana Solari, Milagros Socorro, Karla Suarez, Mayra Santos, David Toscana, Rodrigo Fresan, Juan Forn, Martin Kohan, Jorge Vopli, among others). His teaching centers on the intersection of the interests above and cultural politics.
At Stanford University, he has been Department Chair (1990-91, 1997), and Director of the Center of Latin American Studies (1994, 1997-1998), as well as a member of numerous university and interdepartmental committees. Throughout the years he has been a Jury Member in several international literary prizes and film Festivals: Marcha (Uruguay); Casa de las Américas (La Habana, Cuba); Premio Internacional Juan Rulfo (Guadalajara, Mexico); Festival Internacional del Nuevo Cine Latinoamericano (La Habana, Cuba); Festival Internacional de San Sebastian-Donostia (Pais Vasco, Espana), Festival Internacional de Trieste (Italia).